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Item number: TGM-T67843-100mg

Description: GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation. Target: FAK, PROTACs. Smiles:...

Application:	FAK (PTK2) degradation driving PROTAC
CAS	2743427-26-9
MW:	985.13 D

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GSK215

Item number: Cay40835-10

GSK215 is a proteolysis-targeting chimera (PROTAC) composed of the focal adhesion kinase (FAK) inhibitor PND1186 (Cay-17668) linked to the von-Hippel Lindau (VHL) E3 ligase ligand VHL-021. It binds to the FAK kinase domain (IC50 = 15.8 nM) and induces FAK degradation in A549 lung cancer cells with a 50% degradation...

Keywords:	(2S,4R)-4-hydroxy-1-((S)-2-(2-(4-(3-methoxy-4-((4-((2-(methylcarbamoyl)phenyl)amino)-5-(trifluoromethyl)pyridin-2-yl)amino...
Application:	FAK (PTK2) degradation driving PROTAC
CAS	2743427-26-9
MW:	985.1 D

From 154.00€ *

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