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Item number: TGM-T12438-100mg

Description: PfDHODH-IN-1, an analogue of the active Leflunomide metabolite, exhibits antimalarial activity. Target: Parasite, Dehydrogenase. Smiles: O\C(C1CC1)=C(\C#N)C(=O)Nc1ccc(cc1)C(F)(F)F. References: Li SL, et al. 3D-QSAR studies on a series of dihydroorotate dehydrogenase inhibitors: analogues of the active...

Application:	DHODH inhibitor
CAS	183945-55-3
MW:	296.24 D

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PfDHODH-IN-1

Item number: Cay37728-1

PfDHODH-IN-1 is an inhibitor of dihydroorotate dehydrogenase (DHODH, IC50s = 190, 47, and 21 nM for the human, mouse, and rat enzymes, respectively) and a derivative of the DHODH inhibitor A-771726 (Cay-14404). It inhibits delayed-type hypersensitivity reactions in mice and rats when administered at doses of 30 and...

Keywords:	CCHTFP, PfDHODH Inhibitor 1, 2-cyano-3-cyclopropyl-3-hydroxy-N-[4-(trifluoromethyl)phenyl]-2-propenamide
Application:	DHODH inhibitor
CAS	183945-55-3
MW:	296.2 D

From 35.00€ *

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