Description: Bisindolylmaleimide XI hydrochloride is an orally active PKC inhibitor with inhibitory effects on PKCalpha, PKCbetaI, PKCbetaII, and PKCgamma (IC50s of 9 nM, 28 nM, 31 nM, 37 nM, and 108 nM, respectively). Target: Others. Smiles: Cl.O=C1NC(=O)C(=C1C2=CN(C=3C=CC=CC23)C)C=4C=5C=CC=CC5N6C4CC(CN(C)C)CC6

Bisindolylmaleimide XI (BIM XI) is a selective, cell-permeable protein kinase C (PKC) inhibitor that displays 10-fold greater selectivity for PKCalpha (IC50 = 9 nM) and 4-fold greater selectivity for PKCbetaI (IC50 = 28 nM) over Ca2+-independent PKCepsilon (IC50 = 108 nM). Inhibition of PKCalpha by BIM XI and other...