Description: BRD6688 is a selective HDAC2 inhibitor that acts by enhancing the learning and memory processes. Target: HDAC. Smiles: Nc1ccc(cc1NC(=O)N1CCCC1)-c1ccncc1. References: Kinetically selective inhibitors of histone deacetylase 2 (HDAC2) as cognition enhancers[J]. Chemical Science, 2014, 6(1):804-815.

BRD6688 is an HDAC inhibitor with IC50 values of 21 nM, 100 nM, and 11.48 µM for HDAC1, 2, and 3, respectively. It possesses preferential binding kinetics with six-fold extended half-life on HDAC2 compared to HDAC1 (381 min versus 65 min). BRD6688 crosses the blood brain barrier and has been shown to rescue the...