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Dubermatinib
Item number: TGM-T2005-100mg
Description: Dubermatinib (TP0903) is a potent and selective Axl kinase inhibitor. Target: Apoptosis, TAM Receptor. Smiles: CN(C)S(=O)(=O)c1ccccc1Nc1nc(Nc2ccc(CN3CCN(C)CC3)cc2)ncc1Cl. References: Mollard A, et al. ACS Med Chem Lett. 2011, 2(12), 907-912.
| Keywords: | TP0903 |
| CAS | 1341200-45-0 |
| MW: | 516.06 D |
From 31.00€
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TP-0903
Item number: Cay28757-1
TP-0903 is an inhibitor of the receptor tyrosine kinase Axl (IC50 = 27 nM ). It exhibits greater than 50% inhibition of 11 kinases, including MER, TYRO3, JAK2, ALK, and Abl1, in a panel of 75 kinases at 200 nM, with IC50 values of 3 and 12.4 nM for Aurora A and B, respectively. TP-0903 decreases the phosphorylation...
| Keywords: | 2-[[5-chloro-2-[[4-[(4-methyl-1-piperazinyl)methyl]phenyl]amino]-4-pyrimidinyl]amino]-N,N-dimethyl-benzenesulfonamide |
| Application: | Tyrosine-protein kinase receptor UFO (AXL) inhibitor |
| CAS | 1341200-45-0 |
| MW: | 516.1 D |
From 44.00€
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