Description: KS176 is a potent and selective inhibitor of the breast cancer resistance protein (BCRP) multidrug transporter, exhibiting no inhibitory activity against P-gp or MRP1. Target: BCRP, Potassium Channel. Smiles: OCCc1ccc(NC(=O)c2ccccc2NC(=O)c2ccc(cc2)[N+]([O-])=O)cc1. References: Pick A, et al. Specific...

KS-176 is a selective inhibitor of breast cancer resistance protein (BRCP, IC50 = 1.39 µM) with no activity against P-glycoprotein (P-gp) or multidrug resistance-associated protein 1 (MRP1). It acts as a non-competitive inhibitor whose potency is increased by imatinib binding. KS-176 does not reduce cell viability...