Description: MK-3903, a potent and selective AMPK activator, has an EC50 of 8 nM. Target: AMPK. Smiles: Cc1ccc(Oc2nc3cc(Cl)c(cc3[nH]2)-c2ccc(cc2)-c2ccccc2)cc1C(O)=O. References: Lan P, et al. Hit-to-Lead Optimization and Discovery of 5-((5-([1,1'-Biphenyl]-4-yl)-6-chloro-1H-benzo[d]imidazol-2-yl)oxy)-2-methylbenzoic...

MK-3903 is an activator of AMP-activated protein kinase (AMPK, EC50 = 9 nM). It is selective for AMPK over a kinase panel at 10 µM, as well as the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6 (IC50s = >50 µM for both) and the pregnane X receptor (PXR, EC50 = >30 µM). MK-3903 (30 mg/kg) increases muscle and liver...