Description: DMU2139 is a specific CYP1B1 inhibitor (CYP1B1 and CYP1A1 with IC50 of 9 nM and 795 nM, respectively). Target: P450. Smiles: C(C=CC=1C=CC=NC1)(=O)C2=CC3=C(C=C(OC)C=C3)C=C2. References: Horley N J , Beresford K J M , Chawla T , et al. Discovery and characterization of novel CYP1B1 inhibitors based on...

DMU2139 is an inhibitor of the cytochrome P450 (CYP) isoform CYP1B1 (IC50 = 0.009 µM). It is selective for CYP1B1 over CYP1A1, CYP1A2, CYP3A4, and CYP2D6 (IC50s = 0.795, 1.2, 10.6, and 5 µM, respectively). DMU2139 enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1.Formal Name:...