3 products were found matching "1037624-75-1"!
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Bemcentinib
Item number: TGM-T6269-100mg
Description: Bemcentinib (R428) is a selective inhibitor of Axl (IC50: 14 nM) and has been investigated for the treatment of NSCLC. Target: TAM Receptor. Smiles: Nc1nc(Nc2ccc3CC[C@@H](CCc3c2)N2CCCC2)nn1-c1cc2CCCc3ccccc3-c2nn1. References: Holland SJ, et al. R428, a selective small molecule inhibitor of Axl kinase,...
| Keywords: | R428, BGB324 |
| Application: | Targets AXL receptor tyrosine kinase [EC:2.7.10.1] (AXL, UFO) |
| CAS | 1037624-75-1 |
| MW: | 506.64 D |
From 34.00€
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R428
Item number: Cay21523-1
R428 is a small molecule inhibitor of Axl kinase, both in an in vitro biochemical assay and in a cell-based assay using phosphorylation of Ser473 on Akt as the readout (EC50s = 14 nM for both). It is orally bioavailable, blocks angiogenesis in corneal micropocket and tumor models, and reduces metastatic burden while...
| Keywords: | Bemcentinib, BGB 324,... |
| Application: | Axl kinase inhibitor |
| CAS | 1037624-75-1 |
| MW: | 506.6 D |
From 34.00€
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R-428
Item number: SYN-1131-M001
Soluble in DMSO or ethanol. R428 is a selective inhibitor of the receptor tyrosine kinase AXL. R428 blocks the catalytic and procancerous activities of AXL in vitro. 428 inhibits AXL at low nanomolar values and blocked AXL-dependent events, including Akt phosphorylation, breast cancer cell invasion, and...
| Keywords: | R-428 |
| Application: | AXL inhibitor |
| CAS | 1037624-75-1 |
| MW: | 506,6 D |
From 329.00€
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