Sema3A Sema Domain (human, recombinant, aa 26-546)

Semaphorin-3A (Sema3A) is a secreted glycoprotein and ligand of neuropilin-1 (NRP-1) and plexin A receptors. It is composed of a Sema domain, which mediates signaling and receptor specificity, a plexin-semaphorin-integrin (PSI) domain, an immunoglobulin (Ig) domain, and a C-terminal domain, which contains several basic residues that are important for NRP-1 binding. Sema3A is expressed in many tissues, including nervous, bone, and connective tissues and vascular endothelium, as well as some immune cells such as T cells and macrophages. It is involved in axonal guidance, bone remodeling, immunoregulation, and angiogenesis. Sema3A decreases the length and number of neurites in sensory and motor neurons in vitro and increases vascular permeability in mice. Heterozygous deletion of SEMA3A is associated with Kallmann syndrome, a disorder characterized by hypogonadotropic hypogonadism and an absent or decreased sense of smell. Cayman's Sema3A Sema Domain (human, recombinant, aa 26-546) protein is a disulfide-linked homodimer. The reduced monomer, composed of Sema3A (amino acids 26-546) fused to human IgG1 Fc at its N-terminus, consists of 781 amino acids and has a calculated molecular weight of 87.7 kDa.Synonyms: Sema III, Semaphorin-3A, Semaphorin III. Purity: >90% estimated by SDS-PAGE. Endotoxin Testing: <1.0 EU/µg, determined by the LAL endotoxin assay. Source: Recombinant N-terminal human IgG1 Fc-tagged Sema3A expressed in HEK293 cells. Amino Acids: 26-546. MW: 87.7 kDa. Formulation: (Request formulation change), Lyophilized from sterile PBS, pH 7.4. UniProt Accession #: Q14563.