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NEW
Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
TGM-TMPY-04425-50ug | 50 µg | - |
Request delivery time estimate |
487.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Description: MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase... more
Product information "PRAK/MAPKAPK5 Protein, Human, Recombinant (His & GST)"
Description: MAPKAPK5 contains 1 protein kinase domain and belongs to the protein kinase superfamily, CAMK Ser/Thr protein kinase family. MAPKAPK5 has significant sequence homology to mitogen-activated protein kinase (MAPK)-activated protein kinase (MAPKAPK). It is widely distributed. MAPKAPK5 can be phosphorylated by an extracellular-regulated kinase (ERK), and p38 kinase but not by c-jun N-terminal kinase (JNK)in vitro. Recombinant GST-MAPKAPK5 protein can phosphorylate a peptide derived from the regulatory light chain of myosin II. Phosphorylation of MAPKAPK5 by ERK and p38 kinase increased its activity by 9 and 15 fold respectively. Taken together, these data suggest that MAPKAPK5 is a novel in vitro substrate for ERK and p38 kinase. In response to cellular stress and proinflammatory cytokines, this kinase is activated through its phosphorylation by MAP kinases including MAPK1/ERK, MAPK14/p38-alpha, and MAPK11/p38-beta. MAPKAPK5 also mediates stress-induced small heat shock protein 27 phosphorylation.
Keywords: | MK5, MK-5, MAPKAP-K5, mitogen-activated protein kinase-activated protein kinase 5, PRAK |
Supplier: | TargetMol |
Supplier-Nr: | TMPY-04425 |
Properties
Conjugate: | No |
MW: | 82 kD |
Database Information
KEGG ID : | K04442 | Matching products |
UniProt ID : | Q8IW41 | Matching products |
Gene ID | GeneID 8550 | Matching products |
Handling & Safety
Storage: | +4°C |
Shipping: | +4°C (International: +4°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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