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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
SBB-US0012-C020 | 20 µg | - | - |
3 - 9 business days* |
734.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
p53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending... more
Product information "p53 (polyubiquitinated) (human) (rec.) (His)"
p53 acts as a tumor suppressor in many tumor types, induces growth arrest or apoptosis depending on the physiological circumstances and cell type. Involved in cell cycle regulation as a trans-activator that acts to negatively regulate cell division by controlling a set of genes required for this process. Prevents CDK7 kinase activity when associated to CAK complex in response to DNA damage, thus stopping cell cycle progression. E3 ligase MDM2 mediated ubiquitin conjugation of p53 and subsequent p53 down-regulation via proteasomal degradation interrupts this crucial role, contributing to tumorogenesis (and cancer).
Keywords: | Cellular Tumor Antigen p53, Tumor Suppressor p53, TP53 |
Supplier: | South Bay Bio |
Supplier-Nr: | US0012 |
Properties
Application: | Assays |
Conjugate: | No |
Host: | E.coli |
Species reactivity: | human |
MW: | 40 kD |
Purity: | >95% |
Format: | Liquid |
Database Information
KEGG ID : | K04451 | Matching products |
UniProt ID : | P04637 | Matching products |
Gene ID | GeneID 7157 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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