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![Human APP Protein, His Tag](https://www.biomol.com/media/image/ca/5d/32/DIM-PME100580-10_600x600.jpg)
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You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
Recombinant Human APP Protein with C-terminal 6×His tag. APP(Leu18-Val669) 6×His Tag, Protein... more
Product information "Human APP Protein, His Tag"
Recombinant Human APP Protein with C-terminal 6×His tag. APP(Leu18-Val669) 6×His Tag, Protein function: Functions as a cell surface receptor and performs physiological functions on the surface of neurons relevant to neurite growth, neuronal adhesion and axonogenesis. Interaction between APP molecules on neighboring cells promotes synaptogenesis (PubMed:25122912). Involved in cell mobility and transcription regulation through protein-protein interactions. Can promote transcription activation through binding to APBB1-KAT5 and inhibits Notch signaling through interaction with Numb. Couples to apoptosis- inducing pathways such as those mediated by G(O) and JIP. Inhibits G(o) alpha ATPase activity. Acts as a kinesin I membrane receptor, mediating the axonal transport of beta-secretase and presenilin 1. By acting as a kinesin I membrane receptor, plays a role in axonal anterograde transport of cargo towards synapes in axons (PubMed:17062754, PubMed:23011729). Involved in copper homeostasis/oxidative stress through copper ion reduction. In vitro, copper-metallated APP induces neuronal death directly or is potentiated through Cu(2+)-mediated low-density lipoprotein oxidation. Can regulate neurite outgrowth through binding to components of the extracellular matrix such as heparin and collagen I and IV. The splice isoforms that contain the BPTI domain possess protease inhibitor activity. Induces a AGER-dependent pathway that involves activation of p38 MAPK, resulting in internalization of amyloid-beta peptide and leading to mitochondrial dysfunction in cultured cortical neurons. Provides Cu(2+) ions for GPC1 which are required for release of nitric oxide (NO) and subsequent degradation of the heparan sulfate chains on GPC1. [The UniProt Consortium]
Keywords: | AAA, ABETA, ABPP, AD1, APPI, CTFgamma, CVAP, PN-II, PN2, preA4 |
Supplier: | DIMA |
Supplier-Nr: | PME100580 |
Properties
Conjugate: | No |
Host: | Human cells |
Species reactivity: | human |
MW: | 74.6 kD |
Purity: | >90% (SDS-PAGE) |
Format: | Lyophilized |
Database Information
CAS : | 12| Matching products |
KEGG ID : | K04520 | Matching products |
UniProt ID : | P05067 | Matching products |
Gene ID | GeneID 351 | Matching products |
Handling & Safety
Storage: | -20°C (avoid repeat freezing and thawing cycles) |
Shipping: | +20°C (International: +20°C) |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
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