USP33 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC,

Length: 2487 Sequence: atgacaggat caaattcaca cataacgata ttaaccttaa aggtgttacc tcattttgaa agtcttggga aacaggaaaa aattcctaac aaaatgtcag cttttcgaaa tcattgtcca catttggatt cagttggtga aataacaaaa gaagatttga tacaaaaatc ccttggtact tgtcaggatt gtaaagtcca aggaccaaat ctttgggcat gtctggagaa tagatgttca tatgttggct gtggtgaatc acaagtagat cacagcacca tacattctca ggagacaaag cattatctaa ctgtgaacct taccactctt cgagtatggt gttatgcttg cagcaaagaa gtatttttgg ataggaaatt aggaactcag ccttcattgc ctcatgtaag acaacctcac caaatacaag aaaacagtgt ccaggatttt aaaataccca gtaatacaac attaaaaact cctctggttg ccgtatttga tgatctggat atagaagcgg atgaagaaga tgaacttagg gccagaggtc ttacaggttt gaaaaatatt ggaaatactt gttacatgaa tgcagctttg caggctcttt ctaattgccc acctttgaca cagttttttc ttgattgtgg aggactagct cgaacagata agaaacctgc catttgtaaa agttatctca aactaatgac agagctgtgg cataaaagca ggccaggatc tgttgtgcct actactctgt ttcaaggaat taaaactgta aatccaacat ttcgggggta ttctcagcag gatgctcaag aattccttcg atgtttaatg gatttgcttc atgaagaatt gaaagagcaa gtcatggaag tagaagaaga tccgcaaacc ataaccactg aggagacaat ggaagaagac aagagccagt cggatgtaga ttttcagtct tgtgaatctt gtagcaacag tgatagagca gaaaatgaaa atggctctag atgcttttct gaagataata atgaaacaac aatgttaatt caggatgatg aaaacaattc agaaatgtca aaggattggc aaaaagagaa gatgtgcaat aagattaata aagtaaattc tgaaggcgaa tttgataaag atagagactc tatatctgaa acagtcgact taaacaacca ggaaactgtc aaagtgcaaa tacacagcag agcttcagaa tatatcactg atgtccattc gaatgacctg tctacaccac agatccttcc atcaaatgaa ggtgttaatc cacgtttatc ggcaagccct cctaaatcag gcaatttgtg gccaggattg gcaccaccac acaaaaaagc tcagtctgca tctccaaaga gaaaaaaaca gcacaagaaa tacagaagtg ttatttcaga catatttgat ggaacaatca ttagttcagt gcagtgtctg acttgtgaca gggtgtctgt aaccctcgag acctttcaag atctgtcctt gccaattcct ggcaaggaag accttgctaa gctgcattca tcaagtcatc caacttctat agtcaaagca ggatcatgtg gcgaagcata tgctccacaa gggtggatag cttttttcat ggaatatgtg aagagctggt tttggggtcc agtagtaacc ttgcaagatt gtcttgctgc cttctttgcc agagatgaac taaaaggtga caatatgtac agttgtgaaa aatgcaaaaa gttgagaaat ggagtgaagt tttgtaaagt acaaaacttt cctgagattt tgtgcatcca ccttaaaaga ttcagacatg aactaatgtt ttccaccaaa atcagtaccc atgtttcatt tccgctagaa ggcttggatc ttcagccatt tcttgctaag gatagtccag ctcaaattgt gacatatgat cttctgtcag tcatttgcca tcatggaact gcaagtagtg gacactatat agcctactgc cgaaacaatc taaataatct ctggtatgaa tttgatgatc agagtgtcac tgaagtttca gaatctactg tacaaaatgc agaagcttac gttcttttct ataggaagag cagcgaagag gcacaaaaag agaggagaag gatatcaaat ttattgaaca taatggaacc aagcctcctt cagttttata tttctcgaca gtggcttaat aaatttaaga cctttgccga acctggccct atttcaaata atgactttct ttgtattcat ggaggtgttc ctccaagaaa agctggttat attgaagacc tggttttgat gctgcctcag aacatttggg ataacctata tagcaggtat ggtggaggac cagctgtcaa ccatctgtac atttgtcata cttgccaaat tgaggcggag aaaattgaaa aaagaagaaa aactgaattg gaaattttta ttcgggtaaa Protein function: Deubiquitinating enzyme involved in various processes such as centrosome duplication, cellular migration and beta-2 adrenergic receptor/ADRB2 recycling. Involved in regulation of centrosome duplication by mediating deubiquitination of CCP110 in S and G2/M phase, leading to stabilize CCP110 during the period which centrioles duplicate and elongate. Involved in cell migration via its interaction with intracellular domain of ROBO1, leading to regulate the Slit signaling. Plays a role in commissural axon guidance cross the ventral midline of the neural tube in a Slit-dependent manner, possibly by mediating the deubiquitination of ROBO1. Acts as a regulator of G- protein coupled receptor (GPCR) signaling by mediating the deubiquitination of beta-arrestins (ARRB1 and ARRB2) and beta-2 adrenergic receptor (ADRB2). Plays a central role in ADRB2 recycling and resensitization after prolonged agonist stimulation by constitutively binding ADRB2, mediating deubiquitination of ADRB2 and inhibiting lysosomal trafficking of ADRB2. Upon dissociation, it is probably transferred to the translocated beta-arrestins, leading to beta-arrestins deubiquitination and disengagement from ADRB2. This suggests the existence of a dynamic exchange between the ADRB2 and beta-arrestins. Deubiquitinates DIO2, thereby regulating thyroid hormone regulation. Mediates deubiquitination of both 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. [The UniProt Consortium]