SULT1A1 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC

Length: 888 Sequence: atggagctga tccaggacac ctcccgcccg ccactggagt acgtgaaggg ggtcccgctc atcaagtact ttgcagaggc actggggccc ctgcagagct tccaggcccg gcctgatgac ctgctcatca gcacctaccc caagtccggc actacctggg taagccagat tctggacatg atctaccagg gtggtgacct ggagaagtgt caccgagctc ccatcttcat gcgggtgccc ttccttgagt tcaaagcccc agggattccc tcagggatgg agactctgaa agacacaccg gccccacgac tcctgaagac acacctgccc ctggctctgc tcccccagac tctgttggat cagaaggtca aggtggtcta tgttgcccgc aacgcaaagg atgtggcagt ttcctactac cacttctacc acatggccaa ggtgcaccct gagcctggga cctgggacag cttcctggag aagttcatgg tcggagaagt gtcctacgga tcctggtacc agcacgtgca ggagtggtgg gagctgagcc gcacccaccc tgttctctac ctcttctatg aagacatgaa ggagaacccg aaaagggaga ttcaaaagat cctggagttt gtggggcact ccctgccaga ggagaccgtg gacttcgtgg ttcagcacac gtcgttcaag gagatgaaga agaaccctat gaccaactac accaccgtcc cccaggagtt catggaccac agcatctccc ccttcatgag gaaaggcatg gctggggact ggaagaccac cttcaccgtg gcgcagaatg agcgcttcga tgcggactat gcggagaaga tggcaggctg cagcctcagc ttccgctctg Protein function: Sulfotransferase that utilizes 3'-phospho-5'-adenylyl sulfate (PAPS) as sulfonate donor to catalyze the sulfate conjugation of a wide variety of acceptor molecules bearing a hydroxyl or an amine groupe. Sulfonation increases the water solubility of most compounds, and therefore their renal excretion, but it can also result in bioactivation to form active metabolites. Displays broad substrate specificity for small phenolic compounds. Plays an important role in the sulfonation of endogenous molecules such as steroid hormones and 3,3'-diiodothyronin (PubMed:16221673, PubMed:12471039, PubMed:22069470, PubMed:21723874, PubMed:10199779, PubMed:7834621). Mediates the sulfate conjugation of a variety of xenobiotics, including the drugs acetaminophen and minoxidil. Mediates also the metabolic activation of carcinogenic N-hydroxyarylamines leading to highly reactive intermediates capable of forming DNA adducts, potentially resulting in mutagenesis (PubMed:7834621). [The UniProt Consortium]