PJA2 (Vector Vector will be determined during the manufacturing process, either pENTR223.1 or pUC, A

Length: 2127 Sequence: atgtcacagt acactgaaaa ggagccagca gcaatggacc aagaatctgg taaggctgtc tggcccaaac cagcaggagg gtatcagaca attacaggca ggagatatgg aagaagacat gcttatgtca gttttaaacc atgtatgacc agacatgaaa gaagcttagg tcgggctggt gatgactatg aagtgttgga actagatgat gttccaaagg aaaattcctc aggttccagt cctttggatc aagttgattc ttctttacca agtgaaccta tatttgaaaa aagtgaaaca gaaattccca cttgtggttc agcattgaat caaaccactg agagcagtca atcctttgtt gcagtacatc acagtgagga aggcagggat accttaggaa gcagtacaaa tcttcataat cactctgagg gagagtatat tccaggagct tgtagtgctt caagtgtcca aaatggaatt gcattggttc atacagactc ttatgatcca gatggcaaac atggagaaga taatgaccat cttcaacttt ctgcagaagt cgtggaaggt agtagatacc aggaatcatt aggcaataca gtatttgagt tggaaaacag agaggcagag gcatacactg gtctttcacc accagttccc tcatttaact gtgaagtaag agatgagttt gaagagttag attctgtacc attagtgaaa agttctgctg gtgatactga gtttgtccat cagaatagcc aggaaattca gaggtcttct caagatgaaa tggttagtac gaaacaacaa aataatacta gccaggaaag acagacagaa cattcacctg aagatgcagc ctgtggtcca gggcatattt gtagtgaacg aaataccaat gatagggaaa agaaccatgg aagttctcct gaacaggtag tgaggccaaa agttagaaaa ctgataagtt caagccaggt ggaccaagaa acaggtttta ataggcatga ggcgaaacaa agaagtgttc aaagatggag agaggctttg gaagttgagg aaagtggctc agatgacctc ttaataaaat gtgaagaata tgatggagag catgactgta tgttcttgga tccaccatac tcaagagtta ttacacaaag ggaaacagaa aataaccaaa tgacatcaga aagtggagcc acagcgggaa ggcaagaagt ggataacacc ttttggaatg gctgtggaga ttattaccaa ctctatgaca aagatgaaga tagttctgaa tgcagtgatg gggaatggtc tgcttctttg cctcatcgat tttctggtac agaaaaagat caatcctcaa gtgatgaaag ctgggagact ctgccaggaa aagatgagaa tgaacctgag ctacaaagtg atagcagtgg ccctgaagaa gaaaaccaag aattatctct tcaggaaggg gaacagacat ccttggaaga gggagaaatt ccttggttac agtacaatga agtcaatgaa agcagcagtg atgagggaaa tgaacctgcc aatgaatttg cacagccagc tttcatgttg gatggtaaca ataacctgga ggatgactcc agtgtgagtg aagacttaga tgtggattgg agcatatttg atggctttgc agatggacta ggagttgctg aagctatttc atatgtggat cctcagttcc ttacatacat ggcactagaa gaacgcttag cccaggctat ggagactgct ctggcccatt tagagtctct tgcagtggat gttgaggtgg ccaatccacc agctagtaag gaaagcattg atggtcttcc agagaccctt gttcttgaag atcacactgc tattggtcag gaacaatgct gtccaatctg ttgcagtgag tatattaagg atgatatagc aacagagttg ccctgtcacc atttctttca caaaccttgt gtctcaattt ggctacaaaa gtcgggaaca tgccctgtgt gccgccgtca tttcccacct gcggttattg aagcatctgc agctccttcc tctgagcctg atcctgatgc cccaccttcg aatgacagta ttgcagaagc Protein function: Has E2-dependent E3 ubiquitin-protein ligase activity. Responsible for ubiquitination of cAMP-dependent protein kinase type I and type II-alpha/beta regulatory subunits and for targeting them for proteasomal degradation. Essential for PKA-mediated long-term memory processes. Through the ubiquitination of MFHAS1, positively regulates the TLR2 signaling pathway that leads to the activation of the downstream p38 and JNK MAP kinases and promotes the polarization of macrophages toward the pro-inflammatory M1 phenotype (PubMed:28471450). [The UniProt Consortium]