FBXW5 (Vector pUC, Accession No. BC014130)

Length: 1701 Sequence: atggacgagg gcggcacgcc cctgctcccc gacagcctgg tctaccagat cttcctgagc ctgggcccgg ccgacgtgct ggccgccggg ctggtgtgcc gccaatggca ggccgtgtcg cgggacgagt tcctgtggag ggagcagttc taccgctact accaggtggc ccgcgacgtg ccccgacacc cagcggccat gtcctggtac gaggagttcc agcggctgta tgacacggtg ccctgcgtgg aggtgcagac gctgcgggaa cacacagacc aggtcctgca cctcagcttc tcccattccg ggtaccagtt cgcgtcctgc tccaaggact gcactgtgaa gatctggagc aacgacctga ccatctcgct gctgcacagc gcggacatgc ggccctacaa ctggagctac acccagttct cccagttcaa caaggacgac tcgctactgc tggcctcggg ggtgttcctg gggccgcaca actcctcatc cggcgagatt gctgtcatca gcctagactc cttcgcgctg ctgtcccgcg tgcggaacaa gccctatgac gtgtttggct gttggctcac cgagaccagc ctcatctcgg ggaacctgca ccgcatcgga gatatcacct cctgctcggt gctgtggctc aacaatgcct tccaggatgt ggagtcagag aacgtcaacg tggtgaagcg gctgttcaag atccagaacc tcaatgccag caccgtccgc acggtgatgg tggccgactg cagccgcttc gacagccctg acctgctgct ggaagccggt gacccggcca cgtccccctg ccgcatcttt gacctgggca gcgacaacga ggaggtggtg gctggcccgg cccccgccca cgccaaggag ggcttgcggc actttctgga ccgcgtgctg gaggggcggg cgcagccaca gctgtcggag cgcatgctag agaccaaggt ggccgagctg ctggcccagg gccacaccaa gccacccgag cgcagtgcca caggcgccaa gagcaagtac ctcatcttca ccactggctg cctcacctac tccccacacc agatcggcat caagcagatc ctgccacacc agatgaccac ggcagggccc gtgctgggtg agggccgggg ctccgatgcc ttcttcgacg cgctggacca cgtcatagac atacacggac acatcatcgg catgggcctg tcgcccgaca acaggtacct gtacgtgaac agccgcgcct ggcccaacgg tgcggtggtg gccgacccca tgcagccgcc accaatcgcg gaggagattg acctgctggt gttcgacctc aagaccatgc gggaggtgag gcgggctctg cgtgcgcacc gcgcctacac gcccaacgac gagtgcttct tcatcttcct ggacgtcagc agggacttcg tggccagcgg ggcggaggac cggcacggct acatctggga ccgccactac aacatctgtc tggccaggct gcggcacgag gatgtggtca actcagtggt cttcagtccc caggagcagg agctgctgct cacggccagc gacgacgcca ccatcaaagc ctggcgctcc ccacgcacca tgcgcgtcct ccaggcacct cgcccacggc ctcgcacctt cttctcctgg cttgccagcc agaggcgctg Protein function: Substrate recognition component of both SCF (SKP1-CUL1-F-box protein) and DCX (DDB1-CUL4-X-box) E3 ubiquitin-protein ligase complexes. Substrate recognition component of the SCF(FBXW5) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of SASS6 during S phase, leading to prevent centriole reduplication. The SCF(FBXW5) complex also mediates ubiquitination and degradation of actin-regulator EPS8 during G2 phase, leading to the transient degradation of EPS8 and subsequent cell shape changes required to allow mitotic progression. Substrate-specific adapter of the DCX(FBXW5) E3 ubiquitin-protein ligase complex which mediates the polyubiquitination and subsequent degradation of TSC2. May also act as a negative regulator of MAP3K7/TAK1 signaling in the interleukin-1B (IL1B) signaling pathway. [The UniProt Consortium]