ARPC3 (Vector pUC, Accession No. BC067747)

Length: 537 Sequence: atgccggctt accactcttc tctcatggat cctgatacca aactcatcgg aaacatggca ctgttgccta tcagaagtca attcaaagga cctgccccca gagagacaaa agatacagat attgtggatg aagccatcta ttacttcaag gccaatgtct tcttcaaaaa ctatgaaatt aagaatgaag ctgataggac cttgatatat ataactctct acatttctga atgtctgaag aaactgcaaa agtgcaattc caaaagccaa ggtgagaaag aaatgtatac gctgggaatc actaattttc ccattcctgg agagcctggt tttccactta acgcaattta tgccaaacct gcaaacaaac aggaagatga agtgatgaga gcctatttac aacagctaag gcaagagact ggactgagac tttgtgagaa agttttcgac cctcagaatg ataaacccag caagtggtgg acttgctttg tgaagagaca gttcatgaac aagagtcttt caggacctgg Protein function: Component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF) (PubMed:9230079). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility (PubMed:9230079). In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA (PubMed:29925947). The Arp2/3 complex promotes homologous recombination (HR) repair in response to DNA damage by promoting nuclear actin polymerization, leading to drive motility of double-strand breaks (DSBs) (PubMed:29925947). [The UniProt Consortium]