N-desmethyl Loperamide

Loperamide (Cay-14875) is an opiate which potently and selectively activates µ opioid receptors (Ki = 0.16 nM) exclusively in the periphery. N-desmethyl Loperamide is a major metabolite of loperamide. Like loperamide, N-desmethyl loperamide is a substrate of the ATP-dependent efflux transporter, P-glycoprotein. As a result, both the parent compound and the metabolite display restricted passage through the blood-brain barrier. N-desmethyl Loperamide in biological samples can be analyzed by a variety of methods.Formal Name: 4-(4-chlorophenyl)-4-hydroxy-N-methyl-alpha,alpha-diphenyl-1-piperidinebutanamide. CAS Number: 66164-07-6. Molecular Formula: C28H31ClN2O2. Formula Weight: 463.0. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 2 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 1 mg/ml. SMILES: O=C(NC)C(C1=CC=CC=C1)(C2=CC=CC=C2)CCN3CCC(C4=CC=C(Cl)C=C4)(O)CC3. InChi Code: InChI=1S/C28H31ClN2O2/c1-30-26(32)28(23-8-4-2-5-9-23,24-10-6-3-7-11-24)18-21-31-19-16-27(33,17-20-31)22-12-14-25(29)15-13-22/h2-15,33H,16-21H2,1H3,(H,30,32). InChi Key: ZMOPTLXEYOVARP-UHFFFAOYSA-N.