C22 Ceramide (d18:1/22:0)

C22 ceramide is an endogenous bioactive sphingolipid. Ceramides are involved in permeabilization of the mitochondrial outer membrane during apoptosis via the intrinsic pathway. C22 ceramide forms small channels in liposomes, whereas C16 ceramide (Cay-10681) forms channels that can grow in size, suggesting that acyl chain length of ceramides is important in mitochondrial-mediated apoptosis. In addition, the mitochondrial-to-cytosolic stress response (MCSR) in C. elegans fed C22 ceramide decreases following inhibition of Hsp6 (mortalin/Grp75/mtHsp70) using RNAi.Formal Name: N-[(1S,2R,3E)-2-hydroxy-1-(hydroxymethyl)-3-heptadecen-1-yl]-docosanamide. CAS Number: 27888-44-4. Synonyms: C22 Ceramide, Cer(d18:1/22:0), Ceramide (d18:1/22:0). Molecular Formula: C40H79NO3. Formula Weight: 622.1. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 0.1 mg/ml. SMILES: OC[C@H](NC(CCCCCCCCCCCCCCCCCCCCC)=O)[C@H](O)/C=C/CCCCCCCCCCCCC. InChi Code: InChI=1S/C40H79NO3/c1-3-5-7-9-11-13-15-17-18-19-20-21-22-24-26-28-30-32-34-36-40(44)41-38(37-42)39(43)35-33-31-29-27-25-23-16-14-12-10-8-6-4-2/h33,35,38-39,42-43H,3-32,34,36-37H2,1-2H3,(H,41,44)/b35-33+/t38-,39+/m0/s1. InChi Key: KEPQASGDXIEOIL-GLQCRSEXSA-N.