11beta-Hydroxyprogesterone

11beta-Hydroxyprogesterone (11beta-OHP) is a metabolite of progesterone (Cay-15876). It is an agonist of the mineralocorticoid receptor (MR) that induces MR transactivation in a reporter assay (EC50 = 0.05 µM for COS-7 cells expressing the human receptor). It increases sodium absorption in mpkCCDc14 murine renal cortical collecting duct cells. 11beta-OHP is an inhibitor of 11beta-hydroxysteroid dehydrogenase type 2 (11beta-HSD2) and 11beta-HSD1 (IC50s = 0.140 and 1 µM, respectively). It increases blood pressure in rats when administered subcutaneously at a rate of 10 µg/hour. Serum levels of 11beta-OHP are increased in patients with 21-hydroxylase deficiency, a type of congenital adrenal hyperplasia (CAH), characterized by masculinized genitals in female infants, irregular menses in adult females, and accelerated bone age in adolescent males.Formal Name: 11beta-hydroxy-pregn-4-ene-3,20-dione. CAS Number: 600-57-7. Synonyms: 21-Deoxycorticosterone, 11beta-OHP, 11beta-hydroxy Progesterone, NSC 15469, U-1701. Molecular Formula: C21H30O3. Formula Weight: 330.5. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetone: slightly soluble, Chloroform: slightly soluble, Methanol: slightly soluble. SMILES: C[C@@]12[C@]3([H])[C@](CCC1=CC(CC2)=O)([H])[C@@]4([H])[C@](C[C@@H]3O)([C@H](CC4)C(C)=O)C. InChi Code: InChI=1S/C21H30O3/c1-12(22)16-6-7-17-15-5-4-13-10-14(23)8-9-20(13,2)19(15)18(24)11-21(16,17)3/h10,15-19,24H,4-9,11H2,1-3H3/t15-,16+,17-,18-,19+,20-,21+/m0/s1. InChi Key: BFZHCUBIASXHPK-ATWVFEABSA-N.