(Z)-4-hydroxy Tamoxifen

(Z)-4-hydroxy Tamoxifen is an active metabolite of the estrogen receptor (ER) modulator tamoxifen (Cay-13258). It is primarily formed from tamoxifen by the cytochrome P450 (CYP) isoforms CYP2D6 and CYP2B6. (Z)-4-hydroxy Tamoxifen (10 nM) decreases progesterone receptor (PR) mRNA expression induced by the estrogen steroid 17beta-estradiol (Cay-10006315) in MCF-7 breast cancer cells. Liposomal administration of (Z)-4-hydroxy tamoxifen (4 mg/kg twice per week) reduces tumor growth in an RPMI-8226 multiple myeloma mouse xenograft model.Formal Name: 4-[(1Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-phenol. CAS Number: 68047-06-3. Synonyms: ICI 79280, trans-4-hydroxy Tamoxifen. Molecular Formula: C26H29NO2. Formula Weight: 387.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMSO: 2 mg/ml, Ethanol: 20 mg/ml, Ethanol:PBS (pH 7.2)(1:2): 0.3 mg/ml. lambdamax: 246, 287 nm. SMILES: CC/C(C1=CC=CC=C1)=C(C2=CC=C(OCCN(C)C)C=C2)\C3=CC=C(O)C=C3. InChi Code: InChI=1S/C26H29NO2/c1-4-25(20-8-6-5-7-9-20)26(21-10-14-23(28)15-11-21)22-12-16-24(17-13-22)29-19-18-27(2)3/h5-17,28H,4,18-19H2,1-3H3/b26-25-. InChi Key: TXUZVZSFRXZGTL-QPLCGJKRSA-N.