Umifenovir (hydrochloride)

Umifenovir is a broad-spectrum antiviral agent. It inhibits the replication of H5N1 influenza (IC50 = 30 µg/ml) and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) in vitro (IC50 = 3.537 µM). Umifenovir inhibits entry of hepatitis C virus (HCV) pseudoparticles in Huh7 cells (IC50 = 6 µg/ml) and inhibits Zika virus protein synthesis in Vero cells. In vivo, umifenovir (45 mg/kg) reduces the formation of influenza-induced lung lesions in ferrets.Formal Name: 6-bromo-4-[(dimethylamino)methyl]-5-hydroxy-1-methyl-2-[(phenylthio)methyl]-1H-indole-3-carboxylic acid, ethyl ester, monohydrochloride. CAS Number: 131707-23-8. Synonyms: Arbidol. Molecular Formula: C22H25BrN2O3S . HCl. Formula Weight: 513.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:8): 0.1 mg/ml, DMSO: 15 mg/ml, Ethanol: 10 mg/ml. lambdamax: 225, 255, 315 nm. SMILES: CN1C(CSC2=CC=CC=C2)=C(C(OCC)=O)C3=C(CN(C)C)C(O)=C(Br)C=C31.Cl. InChi Code: InChI=1S/C22H25BrN2O3S.ClH/c1-5-28-22(27)20-18(13-29-14-9-7-6-8-10-14)25(4)17-11-16(23)21(26)15(19(17)20)12-24(2)3,/h6-11,26H,5,12-13H2,1-4H3,1H. InChi Key: OMZHXQXQJGCSKN-UHFFFAOYSA-N.