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Tizoxanide is an active metabolite of the antiparasitic nitazoxanide (Cay-13692). Tizoxanide is formed from nitazoxanide via deacetylation of nitazoxanide in the stomach. It is active against M. tuberculosis (MIC = 16 µg/ml). It also reduces the growth of the disease-causing parasites L. mexicana and T. cruzi in vitro (IC50s = 6.2 and 17.5 µM, respectively), inhibits influenza A replication (EC50s = 0.3-1 µM), and inhibits hepatitis B and hepatitis C virus replication (EC50 = 0.15 µM for both).Formal Name: 2-hydroxy-N-(5-nitro-2-thiazolyl)-benzamide. CAS Number: 173903-47-4. Synonyms: NSC 697856. Molecular Formula: C10H7N3O4S. Formula Weight: 265.3. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 5 mg/ml, DMF:PBS (pH 7.2) (1:9): 0.1 mg/ml, DMSO: 5 mg/ml. SMILES: OC1=C(C(NC2=NC=C([N+]([O-])=O)S2)=O)C=CC=C1. InChi Code: InChI=1S/C10H7N3O4S/c14-7-4-2-1-3-6(7)9(15)12-10-11-5-8(18-10)13(16)17/h1-5,14H,(H,11,12,15). InChi Key: FDTZUTSGGSRHQF-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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