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ThioLox is an inhibitor of 15-lipoxygenase 1 (15-LO-1, Ki = 3.3 µM). It also is an inhibitor of P. falciparum aspartate carbamoyltransferase (IC50 = 3.32 µM). ThioLox (50 µM) reduces LPS-induced expression of the mRNAs encoding TNF-alpha, inducible nitric oxide synthase (iNos), Il-1beta, Il-6, Il-8, and Il-12b in mouse lung slices. It inhibits increases in lipid peroxidation and mitochondrial superoxide formation, as well as cell death, induced by the excitatory neurotransmitter glutamate (L-glutamic acid, Cay-30377) in mouse HT22 hippocampal cells when used at a concentration of 10 µM.Formal Name: 2-amino-N-butyl-5-phenyl-3-thiophenecarboxamide. CAS Number: 1202193-89-2. Molecular Formula: C15H18N2OS. Formula Weight: 274.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 30 mg/ml. lambdamax: 232, 330 nm. SMILES: O=C(NCCCC)C1=C(N)SC(C2=CC=CC=C2)=C1. InChi Code: InChI=1S/C15H18N2OS/c1-2-3-9-17-15(18)12-10-13(19-14(12)16)11-7-5-4-6-8-11/h4-8,10H,2-3,9,16H2,1H3,(H,17,18). InChi Key: QWWMJRJCSZMXHZ-UHFFFAOYSA-N.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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