TAK-243

Item number	Size	Delivery time	Price
TGM-T16974-1mg	1 mg	7 - 10 business days*	41.00€
TGM-T16974-2mg	2 mg	7 - 10 business days*	57.00€
TGM-T16974-5mg	5 mg	7 - 10 business days*	95.00€
TGM-T16974-1mL	1 ml	7 - 10 business days*	107.00€
TGM-T16974-10mg	10 mg	7 - 10 business days*	149.00€
TGM-T16974-25mg	25 mg	7 - 10 business days*	276.00€
TGM-T16974-50mg	50 mg	7 - 10 business days*	473.00€
TGM-T16974-100mg	100 mg	7 - 10 business days*	679.00€

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Description: TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE... more

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Product information "TAK-243"

Description: TAK-243 (MLN7243) is a selective inhibitor of the ubiquitin-activating enzyme UAE (IC50=1 nM), blocking ubiquitin binding and disrupting both mono-ubiquitin signaling and overall protein ubiquitination. TAK-243 exhibits antitumor activity and promotes apoptosis. Target: Apoptosis, E1/E2/E3 Enzyme, NF-kappaB. Smiles: NS(=O)(=O)OC[C@H]1C[C@@H](Nc2ccnc3cc(nn23)-c2cccc(SC(F)(F)F)c2)[C@H](O)[C@@H]1O. References: Zhuang J, et al. Ubiquitin-activating enzyme inhibition induces an unfolded protein response and overcomes drug resistance in myeloma. Blood. 2019 Apr 4,133(14):1572-1584.

Keywords:	MLN7243
Supplier:	TargetMol
Supplier-Nr:	T16974

Properties

Application:	Ubiquitin-like modifier-activating enzyme 1 (UBA1) inhibitor
MW:	519.52 D
Formula:	C19H20F3N5O5S2

Database Information

CAS :	1450833-55-2\| Matching products
KEGG ID :	K03178 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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