Sulfadiazine-d4

Sulfadiazine-d4 is intended for use as an internal standard for the quantification of sulfadiazine (Cay-23719) by GC- or LC-MS. Sulfadiazine is a sulfonamide antibiotic that inhibits the growth of Gram-positive and Gram-negative bacteria. It inhibits dihydropteroate synthase (DHPS), which converts a pteridine and 4-aminobenzoic acid (PABA, Cay-18659) to dihydropteroate, an intermediate in folate biosynthesis. Sulfadiazine inhibits recombinant P. carinii DHPS (IC50 = 0.19 µM). It is active against clinical isolates of M. tuberculosis (MIC90 = 10 mg/L) and of N. meningitidis (MICs = 5-2,000 mg/L). Sulfadiazine is also active against A. pleuropneumoniae, S. choleraesuis, S. typhimurium, P. multocida, S. equi, and S. suis (MIC90s = 16473). In vivo, sulfadiazine (40 mg/kg per day) increases survival in a mouse model of lethal T. gondii infection when administered in combination with pyrimethamine (Cay-16472). Formulations containing sulfadiazine have been used in the treatment of rheumatic fever and various infections, and, in a dual treatment with pyrimethamine, to treat toxoplasmosis.Formal Name: 4-amino-N-2-pyrimidinyl-benzene-2,3,5,6-d4-sulfonamide. CAS Number: 1020719-78-1. Molecular Formula: C10H6D4N4O2S. Formula Weight: 254.3. Purity: >99% deuterated forms (d1-d4). Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: O=S(NC1=NC=CC=N1)(C2=C([2H])C([2H])=C(C([2H])=C2[2H])N)=O. InChi Code: InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)/i2D,3D,4D,5D. InChi Key: SEEPANYCNGTZFQ-QFFDRWTDSA-N.