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Solid. Soluble in DMSO (20mg/ml) or ethanol. Potent and selective cell permeable, ATP-competitive inhibitor of GSK3alpha with an IC50 value of 34nM (and similar potency for GSK3beta), DYRK1A inhibitor (IC50=0.8µM), Stimulates glycogen synthesis in liver cells and induces beta-catenin-dependent gene transcription, Acts as neuroprotectant and prevents neuronal cell death induced by PI3-kinase pathway, Anticancer agent with antiproliferative activity, Reduces pulmonary inflammation and fibrosis in a mouse model, Shown to delay preconditioning, reduces infarct size and prevents cardiac ischemia, Promotes pluripotency in mouse embryonic stem cells, Glycogen synthase kinase 3 (GSK3) is a serine/threonine protein kinase that is inhibited by an assortment of extracellular stimuli such as insulin, growth factors, cell specification factors and cell adhesion. Its activity regulates many cell functions including the control of cell division, apoptosis and inflammation.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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