Phloxine B

Phloxine B is a red dye, the USP grade of which is used as a color additive for food, drugs, and cosmetics. It has also been used as an alternative to Gram staining, to differentiate between Gram-negative and Gram-positive bacteria. At 100 µg/ml, it can inhibit methicillin-resistant S. aureus growth in vitro. Phloxine B has also been shown to modulate channel activity of wild-type cystic fibrosis transmembrane conductance regulator chloride channels (CFTR, Ki = 38 µM) and mutant delta F508 CFTR (Ki = 33 µM).Formal Name: 2',4',5',7'-tetrabromo-4,5,6,7-tetrachloro-3',6'-dihydroxy-spiro[isobenzofuran-1(3H),9'-[9H]xanthen]-3-one, disodium salt. CAS Number: 18472-87-2. Synonyms: Acid Red 92, Cyanosine, D&C Red No. 28. Molecular Formula: C20H2Br4Cl4O5 . 2Na. Formula Weight: 829.6. Purity: >95%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/ml, DMSO: 30 mg/ml, Ethanol: 2 mg/ml, PBS (pH 7.2): 10 mg/ml. lambdamax: 551 nm. SMILES: BrC1=C([O-])C(Br)=CC2=C1OC3=C(Br)C([O-])=C(Br)C=C3C24C(C(Cl)=C(Cl)C(Cl)=C5Cl)=C5C(O4)=O.[Na+].[Na+]. InChi Code: InChI=1S/C20H4Br4Cl4O5.2Na/c21-5-1-3-17(9(23)15(5)29)32-18-4(2-6(22)16(30)10(18)24)20(3)8-7(19(31)33-20)11(25)13(27)14(28)12(8)26,,/h1-2,29-30H,,/q,2*+1/p-2. InChi Key: OOYIOIOOWUGAHD-UHFFFAOYSA-L.