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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay25746-500 | 500 µg | - |
6 - 10 business days* |
344.00€
|
|||
Cay25746-1 | 1 mg | - |
6 - 10 business days* |
649.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
PGPC-d6 is intended for use as an internal standard for the quantification of PGPC (Cay-10044),... more
Product information "PGPC-d6"
PGPC-d6 is intended for use as an internal standard for the quantification of PGPC (Cay-10044), as well as related fragmented short-chain fatty acid remnants of phospholipid oxidation, by GC- or LC-MS. PGPC is an oxidized phospholipid that can be formed under conditions of oxidative stress. It is found as a component in mildly oxidized LDL (MM-LDL) and in products formed from the oxidation of 1-palmitoyl-2-arachidonoyl-sn-glycero-3-phosphocholine (Ox-PAPC). PGPC activates peroxisome proliferator-activated receptor alpha (PPARalpha) in a concentration-dependent manner in a cell-based ligand-binding assay. It increases VCAM1 and E-selectin expression in human aortic endothelial cells (HAECs), as well as HAEC binding by monocytes and polymorphonuclear neutrophils (PMNs), in a concentration-dependent manner. PGPC (37.5 µM) also increases total 5-lipoxygenase metabolites in murine resident peritoneal macrophages (RPMs) and induces apoptosis in A7r5 rat aortic smooth muscle cells in vitro when used at a concentration of 50 µM. PGPC levels are increased in serum, LDL, and peripheral blood mononuclear cells (PBMCs) of patients with coronary artery disease. UVA irradiation increases PGPC levels in cultured human skin fibroblasts.Formal Name: (R)-2-((4-carboxybutanoyl-2,2,3,3,4,4-d6)oxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate. Synonyms: 1-Palmitoyl-2-glutaryl Phosphatidylcholine-d6. Molecular Formula: C29H50D6NO10P. Formula Weight: 615.8. Purity: >99% deuterated forms (d1-d6). Formulation: (Request formulation change), A solution in ethanol. Solubility: DMSO: 1 mg/ml, Ethanol: 20 mg/ml, PBS (pH 7.2): 5 mg/ml. lambdamax: 292 nm. SMILES: O=P(OCC[N+](C)(C)C)([O-])OC[C@H](OC(C([2H])([2H])C([2H])([2H])C([2H])([2H])C(O)=O)=O)COC(CCCCCCCCCCCCCCC)=O. InChi Code: InChI=1S/C29H56NO10P/c1-5-6-7-8-9-10-11-12-13-14-15-16-17-20-28(33)37-24-26(40-29(34)21-18-19-27(31)32)25-39-41(35,36)38-23-22-30(2,3)4/h26H,5-25H2,1-4H3,(H-,31,32,35,36)/t26-/m1/s1/i18D2,19D2,21D2. InChi Key: CDZVJFRXJAUXPP-KXHOITNYSA-N. Side Chain Carbon Sum: 21:0.
Keywords: | 1-Palmitoyl-2-glutaryl Phosphatidylcholine-d6, (R)-2-((4-carboxybutanoyl-2,2,3,3,4,4-d6)oxy)-3-(palmitoyloxy)propyl (2-(trimethylammonio)ethyl) phosphate |
Supplier: | Cayman Chemical |
Supplier-Nr: | 25746 |
Properties
Application: | Oxidized phospholipid, GC-MS, LC-MS, internal standard |
MW: | 615.8 D |
Formula: | C29H50D6NO10P |
Purity: | >99% deuterated forms (d1-d6) |
Format: | Solution |
Database Information
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Danger |
GHS Hazard Pictograms: |
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H Phrases: | H225, H319, H333 |
P Phrases: | P210, P233, P240, P241, P242, P243, P264, P280, P303+361+353, P304+312, P305+351+338, P337+313, P370+378, P403+235, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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