PF-00446687

PF-00446687 is an agonist of melanocortin receptor 4 (MC4R). It selectively activates adenylyl cyclase in HEK293 cells expressing MC4R (EC50 = 0.012 µM) over HEK293 cells expressing MC1R, MC3R, or MC5R (EC50s = 1.02, 1.16, and 1.98 µM, respectively). PF-00446687 (1 mg/kg per day) increases time spent huddling and in close contact with chosen partners in prairie voles.Formal Name: [(3S,4R)-4-(2,4-difluorophenyl)-1-(1,1-dimethylethyl)-3-pyrrolidinyl][(3R,5S)-4-hydroxy-3,5-dimethyl-4-phenyl-1-piperidinyl]-methanone. CAS Number: 862281-92-3. Synonyms: PF446687. Molecular Formula: C28H36F2N2O2. Formula Weight: 470.6. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Acetonitrile: Slightly soluble: 0.1-1 mg/ml, DMSO: Solvent Solubility, Water: Slightly soluble: 0.1-1 mg/ml. SMILES: C[C@H]1CN(C([C@H]2[C@H](C3=CC=C(F)C=C3F)CN(C(C)(C)C)C2)=O)C[C@@H](C)[C@]1(O)C4=CC=CC=C4. InChi Code: InChI=1S/C28H36F2N2O2/c1-18-14-31(15-19(2)28(18,34)20-9-7-6-8-10-20)26(33)24-17-32(27(3,4)5)16-23(24)22-12-11-21(29)13-25(22)30/h6-13,18-19,23-24,34H,14-17H2,1-5H3/t18-,19+,23-,24+,28-/m0/s1. InChi Key: WHPJOAUPIZDJNX-AGGGUQDCSA-N.