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Description: P053 is a potent, non-competitive, and selective ceramide synthase 1 (CerS1) inhibitor with an IC50 of 0.5 µM. It acts as an endogenous inhibitor of mitochondrial fatty acid oxidation in muscle and regulates whole-body adiposity[1]. Target: Others. Smiles: C[C@@](N)(CO)CCc1ccc(OCc2ccc(Cl)c(Cl)c2)cc1. References: Turner N, et al. A selective inhibitor of ceramide synthase 1 reveals a novel role in fat metabolism. Nat Commun. 2018 Aug 21,9(1):3165.
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