O-304

O-304
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay26186-1 1 mg -

6 - 10 business days*

80.00€
Cay26186-5 5 mg -

6 - 10 business days*

320.00€
Cay26186-10 10 mg -

6 - 10 business days*

600.00€
 
O-304 is a pan-activator of AMP-activated protein kinase (AMPK). It increases levels of... more
Product information "O-304"
O-304 is a pan-activator of AMP-activated protein kinase (AMPK). It increases levels of phosphorylated AMPK (pAMPK) without reducing cellular ATP. O-304 suppresses dephosphorylation of AMPKalpha, AMPKbeta, and AMPKgamma trimers at threonine 172 (T172) mediated by protein phosphatase 2C (PP2C) without inhibiting PP2C activity in Wi-38 lung fibroblasts. In vivo, O-304 (100 mg/kg) prevents high-fat diet-induced increases in fasted glucose and plasma insulin levels and development of insulin resistance, as well as increases calf muscle pAMPK levels in mice.Formal Name: 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-benzamide. CAS Number: 1261289-04-6. Molecular Formula: C16H11Cl2N3O2S. Formula Weight: 380.2. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMSO: 10 mg/ml, DMSO:PBS (pH 7.2) (1:30): 0.03 mg/ml, Ethanol: slightly soluble. lambdamax: 256, 320 nm. SMILES: ClC1=CC=C(CN2SC(NC(C3=CC=C(Cl)C=C3)=O)=NC2=O)C=C1. InChi Code: InChI=1S/C16H11Cl2N3O2S/c17-12-5-1-10(2-6-12)9-21-16(23)20-15(24-21)19-14(22)11-3-7-13(18)8-4-11/h1-8H,9H2,(H,19,20,22,23). InChi Key: WEDWLYRQKUTOAX-UHFFFAOYSA-N.
Keywords: 4-chloro-N-[2-[(4-chlorophenyl)methyl]-2,3-dihydro-3-oxo-1,2,4-thiadiazol-5-yl]-benzamide
Supplier: Cayman Chemical
Supplier-Nr: 26186

Properties

Application: AMPK activator
MW: 380.2 D
Formula: C16H11Cl2N3O2S
Purity: >98%

Database Information

CAS : 1261289-04-6| Matching products
KEGG ID : K07198 | Matching products

Handling & Safety

Storage: -20°C
Shipping: -20°C (International: -20°C)
Caution
Our products are for laboratory research use only: Not for administration to humans!
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