Nobiletin

Nobiletin is a polymethoxylated flavonoid that has been found in C. unshiu and has diverse biological activities. It reduces LPS- and IFN-gamma-induced increases in inducible nitric oxide synthase (iNOS) protein levels and NO production in RAW 264.7 cells when used at concentrations of 25, 50, and 100 µM. Nobiletin decreases proliferation of A549 lung, B16/4A5 melanoma, CCRF-HSB-2 leukemia, and TGBC11TKB gastric cancer cell lines with IC50 values of 22, 18, 13, and 8.3 µM, respectively. Dietary administration of nobiletin (0.3% w/w) reduces body weight, hepatic steatosis, and plasma LDL and HDL cholesterol levels in mice fed a high-fat, high-cholesterol diet for 18 weeks. It also inhibits increases in plasma glucose levels in an intraperitoneal glucose tolerance test in the same model.Formal Name: 2-(3,4-dimethoxyphenyl)-5,6,7,8-tetramethoxy-4H-1-benzopyran-4-one. CAS Number: 478-01-3. Synonyms: NSC 76751, NSC 618903. Molecular Formula: C21H22O8. Formula Weight: 402.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 15 mg/ml, DMF:PBS(pH 7.2)(1:1): 0.5 mg/ml, DMSO: 10 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 208, 248, 271, 333 nm. SMILES: O=C1C2=C(OC)C(OC)=C(OC)C(OC)=C2OC(C3=CC=C(OC)C(OC)=C3)=C1. InChi Code: InChI=1S/C21H22O8/c1-23-13-8-7-11(9-15(13)24-2)14-10-12(22)16-17(25-3)19(26-4)21(28-6)20(27-5)18(16)29-14/h7-10H,1-6H3. InChi Key: MRIAQLRQZPPODS-UHFFFAOYSA-N. Origin: Plant/Citrus reticulata Blanco.