MLN4760

MLN4760 is an inhibitor of angiotensin-converting enzyme 2 (ACE2, IC50 = 0.44 nM). It is selective for ACE2 over ACE and carboxypeptidase A (CPDA, IC50s = >100 and 27 µM, respectively). MLN4760 inhibits ACE2 hydrolysis of angiotensin I in vitro when used at a concentration of 1 µM. It also inhibits the protein-protein interaction between ACE2 and the severe acute respiratory coronavirus 2 (SARS-CoV-2) spike glycoprotein, also known as the surface glycoprotein. In vivo, MLN4760 inhibits exogenous recombinant ACE2-induced prevention of angiotensin II-induced hypertension in mice.Formal Name: N-[(1S)-1-carboxy-3-methylbutyl]-3-[(3,5-dichlorophenyl)methyl]-L-histidine. CAS Number: 305335-31-3. Synonyms: GL-1001. Molecular Formula: C19H23Cl2N3O4. Formula Weight: 428.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. SMILES: CC(C)C[C@@H](C(O)=O)N[C@H](C(O)=O)CC1=CN=CN1CC2=CC(Cl)=CC(Cl)=C2. InChi Code: InChI=1S/C19H23Cl2N3O4/c1-11(2)3-16(18(25)26)23-17(19(27)28)7-15-8-22-10-24(15)9-12-4-13(20)6-14(21)5-12/h4-6,8,10-11,16-17,23H,3,7,9H2,1-2H3,(H,25,26)(H,27,28)/t16-,17-/m0/s1. InChi Key: NTCCRGGIJNDEAB-IRXDYDNUSA-N.