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Description: ML162 is an inhibitor of GPX4 that is selectively lethal to mutant RAS oncogene-expressing cell lines (IC50s = 25 and 578 nM for HRASG12V-expressing and wild-type BJ fibroblasts, respectively). Target: GPX, Glutathione Peroxidase, Ferroptosis. Smiles: COc1ccc(cc1Cl)N(C(C(=O)NCCc1ccccc1)c1cccs1)C(=O)CCl. References: WeiWer M , Bittker J A , Lewis T A , et al. Development of small-molecule probes that selectively kill cells induced to express mutant RAS[J]. Bioorganic & Medicinal Chemistry Letters, 2012, 22(4):1822-1826.
This website uses cookies, which are necessary for the technical operation of the website and are always set. Other cookies, which increase the usability of this website, serve for direct advertising or simplify interaction with other websites and social networks, will only be used with your consent.
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