MK-3903

MK-3903 is an activator of AMP-activated protein kinase (AMPK, EC50 = 9 nM). It is selective for AMPK over a kinase panel at 10 µM, as well as the cytochrome P450 (CYP) isoforms CYP3A4 and CYP2D6 (IC50s = >50 µM for both) and the pregnane X receptor (PXR, EC50 = >30 µM). MK-3903 (30 mg/kg) increases muscle and liver levels of phosphorylated ACC, an AMPK substrate, and reduces insulin resistance in diet-induced obese (DIO) mice. It inhibits hepatic fatty acid synthesis in db/db mice when administered at doses ranging from 3 to 30 mg/kg.Formal Name: 5-[(5-[1,1'-biphenyl]-4-yl-6-chloro-1H-benzimidazol-2-yl)oxy]-2-methyl-benzoic acid. CAS Number: 1219737-12-8. Molecular Formula: C27H19ClN2O3. Formula Weight: 454.9. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10mg/mL, DMSO: 15mg/mL, DMSO:PBS (pH 7.2) (1:2): 0.3mg/mL, Ethanol: 0.2mg/mL. lambdamax: 247, 279 nm. SMILES: ClC(C=C(N=C(OC1=CC=C(C)C(C(O)=O)=C1)N2)C2=C3)=C3C(C=C4)=CC=C4C5=CC=CC=C5. InChi Code: InChI=1S/C27H19ClN2O3/c1-16-7-12-20(13-21(16)26(31)32)33-27-29-24-14-22(23(28)15-25(24)30-27)19-10-8-18(9-11-19)17-5-3-2-4-6-17/h2-15H,1H3,(H,29,30)(H,31,32). InChi Key: FIKQZQDYGXAUHC-UHFFFAOYSA-N.