GW 405833

GW 405833 is a partial agonist of the cannabinoid CB2 receptor (EC50 = 0.65 nM). It is selective for CB2, binding with a Ki value of 14 nM compared to that of CB1 with a Ki value of 2.04 µM. GW 405833 demonstrates anti-inflammatory and antihyperalgesic properties in animal models of inflammation and pain.Formal Name: (2,3-dichlorophenyl)[5-methoxy-2-methyl-3-[2-(4-morpholinyl)ethyl]-1H-indol-1-yl]-methanone. CAS Number: 180002-83-9. Synonyms: L-768,242. Molecular Formula: C23H24Cl2N2O3. Formula Weight: 447.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 10 mg/ml, DMF:PBS (pH 7.2) (1:4): 0.2 mg/ml, DMSO: 5 mg/ml, Ethanol: 0.3 mg/ml. lambdamax: 264, 315 nm. SMILES: COC1=CC=C(N(C(C2=C(Cl)C(Cl)=CC=C2)=O)C(C)=C3CCN4CCOCC4)C3=C1. InChi Code: InChI=1S/C23H24Cl2N2O3/c1-15-17(8-9-26-10-12-30-13-11-26)19-14-16(29-2)6-7-21(19)27(15)23(28)18-4-3-5-20(24)22(18)25/h3-7,14H,8-13H2,1-2H3. InChi Key: FSFZRNZSZYDVLI-UHFFFAOYSA-N.