GSK621

GSK621 is an activator of AMP-activated protein kinase (AMPK). It has been shown to increase phosphorylation at AMPKalpha T172, a marker of AMPK activation, in both acute myeloid leukemia (AML) cell lines and primary AML samples. GSK621 is reported to reduce the proliferation of AML cell lines (IC50s = 13-30 µM), triggering autophagy via the eIF2alpha/ATF4 signaling pathway.Formal Name: 6-chloro-5-(2'-hydroxy-3'-methoxy[1,1'-biphenyl]-4-yl)-3-(3-methoxyphenyl)-1H-pyrrolo[3,2-d]pyrimidine-2,4(3H,5H)-dione. CAS Number: 1346607-05-3. Molecular Formula: C26H20ClN3O5. Formula Weight: 489.9. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 30 mg/mL, DMSO: 30 mg/mL, DMSO:PBS(pH 7.2) (1:3): 0.25 mg/mL. lambdamax: 273 nm. SMILES: COC1=CC=CC(N2C(C(N(C3=CC=C(C4=CC=CC(OC)=C4O)C=C3)C(Cl)=C5)=C5NC2=O)=O)=C1. InChi Code: InChI=1S/C26H20ClN3O5/c1-34-18-6-3-5-17(13-18)30-25(32)23-20(28-26(30)33)14-22(27)29(23)16-11-9-15(10-12-16)19-7-4-8-21(35-2)24(19)31/h3-14,31H,1-2H3,(H,28,33). InChi Key: KURYSXLJGKKDHT-UHFFFAOYSA-N.