GSK215

Item number	Size	Delivery time	Price
TGM-T67843-1mg	1 mg	7 - 10 business days*	124.00€
TGM-T67843-5mg	5 mg	7 - 10 business days*	310.00€
TGM-T67843-10mg	10 mg	7 - 10 business days*	486.00€
TGM-T67843-25mg	25 mg	7 - 10 business days*	812.00€
TGM-T67843-50mg	50 mg	7 - 10 business days*	1,127.00€
TGM-T67843-100mg	100 mg	7 - 10 business days*	1,520.00€

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Description: GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50=... more

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Product information "GSK215"

Description: GSK215 is a potent and selective PROTAC focal adhesion kinase (FAK) degrader (pDC50= 8.4), designed using the FAK inhibitor VS-4718 and a binder for the VHL E3 ligase, capable of inducing rapid and prolonged FAK degradation. Target: FAK, PROTACs. Smiles: CNC(=O)c1ccccc1Nc1cc(Nc2ccc(cc2OC)N2CCN(CC(=O)N[C@H](C(=O)N3C[C@H](O)C[C@H]3C(=O)N[C@@H](C)c3ccc(cc3)-c3scnc3C)C(C)(C)C)CC2)ncc1C(F)(F)F. References: Law RP, Nunes J, Chung CW, et al. Discovery and Characterisation of Highly Cooperative FAK-Degrading PROTACs [published online ahead of print, 2021 Aug 20]. Angew Chem Int Ed Engl. 2021,10.1002/anie.202109237.

Supplier:	TargetMol
Supplier-Nr:	T67843

Properties

Application:	FAK (PTK2) degradation driving PROTAC
MW:	985.13 D
Formula:	C50H59F3N10O6S

Database Information

CAS :	2743427-26-9\| Matching products
KEGG ID :	K05725 \| Matching products

Handling & Safety

Storage:	+4°C
Shipping:	+4°C (International: +4°C)

Caution
Our products are for laboratory research use only: Not for administration to humans!

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