GPX4 16

GPX4 16 is an inhibitor of glutathione peroxidase 4 (GPX4). It inhibits the proliferation of Nthy-ori-3-1 transformed human thyroid follicular epithelial cells (IC50 = 8.39 µM), as well as MDA-T32 and MDA-T41 human thyroid cancer cells (IC50s = 10.29 and 8.18 µM, respectively). GPX4 16 (10 µM) induces ferroptosis in MDA-T32 cells, an effect that can be prevented by the ferroptosis inhibitor ferrostatin-1 (Cay-17729). It reduces GPX4 protein levels in MDA-T32 cells when used at a concentration of 0.3 µM. GPX4 16 also induces the production of reactive oxygen species (ROS) and reduces glutathione (GSH) levels, mitochondrial polarization, and mitochondrial respiration in MDA-T32 cells.Formal Name: 4-[(2E)-3-[2-(2-formylphenoxy)phenyl]-1-oxo-2-propen-1-yl]-benzonitrile. CAS Number: 2644044-43-7. Synonyms: Glutathione Peroxidase 4 16. Molecular Formula: C23H15NO3. Formula Weight: 353.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Sparingly soluble: 1-10 mg/ml. SMILES: O=C(C1=CC=C(C#N)C=C1)/C=C/C2=CC=CC=C2OC3=CC=CC=C3C=O. InChi Code: InChI=1S/C23H15NO3/c24-15-17-9-11-18(12-10-17)21(26)14-13-19-5-1-3-7-22(19)27-23-8-4-2-6-20(23)16-25/h1-14,16H/b14-13+. InChi Key: UNQJNKUGIZRZER-BUHFOSPRSA-N.