Glutaminase Inhibitor Compound 968

Glutaminase inhibitor compound 968 is a cell-permeable, reversible inhibitor of a mitochondrial glutaminase splice variant, glutaminase C (IC50 = ~2.5 µM), which is commonly found in cancer cells. Through this action, glutaminase inhibitor compound 968 blocks transformation induced by Rho GTPases and inhibits the proliferation of non-invasive epithelial (T-47D and MDA-MB-361) and invasive mesenchymal (MDA-MB-231 and Hs578T) cancer cells, without affecting normal cells. Glutaminase inhibitor compound 968 induces apoptosis and alters both histone methylation and gene expression in cancer cells.Formal Name: 5-[3-bromo-4-(dimethylamino)phenyl]-2,3,5,6-tetrahydro-2,2-dimethyl-benzo[a]phenanthridin-4(1H)-one. CAS Number: 311795-38-7. Molecular Formula: C27H27BrN2O. Formula Weight: 475.4. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 16 mg/ml, DMF:PBS (pH 7.2) (1:2): 0.3 mg/ml, DMSO: 14 mg/ml, Ethanol: 0.5 mg/ml. lambdamax: 216, 232, 281, 292, 339, 371 nm. SMILES: CC(C1)(C)CC(C2=C1C(C(C=CC=C3)=C3C=C4)=C4NC2C5=CC(Br)=C(N(C)C)C=C5)=O. InChi Code: InChI=1S/C27H27BrN2O/c1-27(2)14-19-24-18-8-6-5-7-16(18)9-11-21(24)29-26(25(19)23(31)15-27)17-10-12-22(30(3)4)20(28)13-17/h5-13,26,29H,14-15H2,1-4H3. InChi Key: NVFRRJQWRZFDLM-UHFFFAOYSA-N.