Fucoidan

Fucoidan is a sulfated polysaccharide that has been found in various brown algae species, including L. digitata, A. nodosum, M. pyrifera, and F. vesiculosus, and has diverse biological activities. Fucoidan consists of repeated (1->3)-L-fucopyranoses or alternating and repeated (1->3)- and (1->4)-L-fucopyranoses, as well as R groups composed of sulfate, uronic acid, or fucose groups. It also contains other sugars such as galactose. It has antioxidant activity in ferric reducing and DPPH (Cay-14805) scavenging assays (IC50s = 76.8 and 93.69 µg/ml, respectively). Fucoidan inhibits herpes simplex virus 1 (HSV-1) and HSV-2 replication in Vero cells (IC50s = 2.5 and 2.6 µg/ml, respectively). It also inhibits thrombin-induced aggregation of isolated human platelets when used at a concentration of 100 µg/ml. Fucoidan (4 mg/kg) decreases neutrophil infiltration in a rat model of peptone-induced acute peritonitis. It reduces tumor growth, inhibits angiogenesis, and decreases the number of lung metastases in a 4T1 murine model of breast cancer when administered at doses of 5 and 10 mg/kg. Formulations containing fucoidan have been used as dietary supplements.Formal Name: (2S,3S,4S,5S,6R)-4-hydroxy-5-methoxy-2,6-dimethyltetrahydro-2H-pyran-3-yl hydrogen sulfate. CAS Number: 9072-19-9. Synonyms: Fucan, Sulfated alpha-L-Fucan. Molecular Formula: (C6H9O3SO3)n. Purity: >85%. Formulation: (Request formulation change), A crystalline solid. Solubility: PBS (pH 7.2): 1 mg/ml. SMILES: C[C@H]1O[C@H](OC2[C@H](C)O[C@@H](OC3[C@H](O[R])[C@H](C)O[C@@H](OC4[C@H](C)O[C@@H](C)[C@@H](O[R])[C@@H]4O[R])[C@H]3O[R])[C@@H](O[R])[C@@H]2O[R])[C@H](O[R])[C@@H](OC)[C@H]1O[R].CC.CC. Origin: Plant/Laminaria japonica.