Fluvastatin

Fluvastatin
Item number Size Datasheet Manual SDS Delivery time Quantity Price
Cay10010334-10 10 mg -

6 - 10 business days*

54.00€
Cay10010334-25 25 mg -

6 - 10 business days*

119.00€
Cay10010334-50 50 mg -

6 - 10 business days*

196.00€
Cay10010334-100 100 mg -

6 - 10 business days*

340.00€
 
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also... more
Product information "Fluvastatin"
Fluvastatin is an inhibitor of HMG-CoA reductase (Ki = 0.3 nM for the rat enzyme). It also inhibits the human cytochrome P450 (CYP) isoform CYP2C9 (IC50 = 100 nM). Fluvastatin inhibits oxidized LDL-induced ferroptosis and reverses oxidized LDL-induced decreases in glutathione peroxidase 4 (GPX4) and system Xc- cystine-glutamate antiporter levels in human umbilical vein endothelial cells (HUVECs). In vivo, fluvastatin (2 mg/kg per day) decreases serum cholesterol, triglyceride, and phospholipid levels, the formation of thiobarbituric acid-reactive substances (TBARS), and vascular angiotensin-converting enzyme (ACE) activity in rabbits fed a high-cholesterol diet. It increases survival in a mouse model of myocardial infarction when administered at a dose of 10 mg/kg per day. Formulations containing fluvastatin have been used in the treatment of hypercholesterolemia and the prevention of cardiovascular disease.Formal Name: (3R,5S,6E)-rel-7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid. CAS Number: 93957-54-1. Synonyms: NSC 758896. Molecular Formula: C24H26FNO4. Formula Weight: 411.5. Purity: >98%. Formulation: (Request formulation change), A crystalline solid. Solubility: DMF: 20 mg/ml, DMF:PBS (pH 7.2) (1:1): 0.5 mg/ml, DMSO: 14 mg/ml, Ethanol: 1 mg/ml. lambdamax: 236, 305 nm. SMILES: FC1=CC=C(C=C1)C2=C(/C=C/[C@H](O)C[C@H](O)CC(O)=O)N(C(C)C)C3=C2C=CC=C3. InChi Code: InChI=1S/C24H26FNO4/c1-15(2)26-21-6-4-3-5-20(21)24(16-7-9-17(25)10-8-16)22(26)12-11-18(27)13-19(28)14-23(29)30/h3-12,15,18-19,27-28H,13-14H2,1-2H3,(H,29,30)/b12-11+/t18-,19-/m0/s1. InChi Key: FJLGEFLZQAZZCD-JUFISIKESA-N.
Keywords: 7-[3-(4-fluorophenyl)-1-(1-methylethyl)-1H-indol-2-yl]-3,5-dihydroxy-6-heptenoic acid
Supplier: Cayman Chemical
Supplier-Nr: 10010334

Properties

Application: HMG-CoA reductase inhibitor
MW: 411.5 D
Formula: C24H26FNO4
Purity: >98%
Format: Crystalline Solid

Database Information

CAS : 93957-54-1| Matching products
KEGG ID : K00021 | Matching products

Handling & Safety

Storage: -20°C
Shipping: +20°C (International: -20°C)
Signal Word: Danger
GHS Hazard Pictograms:
H Phrases: H302, H315, H318, H350, H402, H412
P Phrases: P201, P202, P264, P270, P273, P280, P301+310, P302+352, P305+351+338, P308+313, P310, P321, P330, P332+313, P362+364, P405, P501
Caution
Our products are for laboratory research use only: Not for administration to humans!
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