Finerenone

Finerenone is a non-steroidal mineralocorticoid receptor antagonist (IC50 = 18 nM). It is selective for the mineralocorticoid receptor over glucocorticoid, progesterone, and androgen receptors (IC50s = >10,000 nM for all), as well as L-type calcium channels (IC50 = >10,000 nM). Finerenone (3 mg/kg) reduces renal vasculopathy, fibrosis, and tubular degeneration, as well as cardiac fibrosis, in a rat model of hypertension-induced end-organ damage. It also increases exercise capacity and prevents diastolic dysfunction in ovariectomized mice.Formal Name: (4S)-4-(4-cyano-2-methoxyphenyl)-5-ethoxy-1,4-dihydro-2,8-dimethyl-1,6-naphthyridine-3-carboxamide. CAS Number: 1050477-31-0. Synonyms: BAY 94-8862. Molecular Formula: C21H22N4O3. Formula Weight: 378.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml, DMSO: 3 mg/ml, Ethanol: insol, PBS (pH 7.2): insol. lambdamax: 255 nm. SMILES: CCOC1=C2[C@@H](C3=C(C=C(C=C3)C#N)OC)C(C(N)=O)=C(NC2=C(C=N1)C)C. InChi Code: InChI=1S/C21H22N4O3/c1-5-28-21-18-17(14-7-6-13(9-22)8-15(14)27-4)16(20(23)26)12(3)25-19(18)11(2)10-24-21/h6-8,10,17,25H,5H2,1-4H3,(H2,23,26)/t17-/m0/s1. InChi Key: BTBHLEZXCOBLCY-KRWDZBQOSA-N.