Ferroptosis Inducer 24

Ferroptosis inducer 24 is an inducer of ferroptosis. It inhibits glutathione peroxidase 4 (GPX4) by 30-35% when used at a concentration of 50 µM. Ferroptosis inducer 24 (10 µM) increases the levels of heme oxygenase-1 (HO-1) in MDA-MB-231 triple-negative breast cancer cells, as well as increases the levels of bilirubin formed by HO-1 in MDA-MB-231 cell lysates. It reduces the viability of, as well as increases the levels of oxidized lipids, decreases the levels of IL-6 and glutathione (GST), and disrupts the mitochondrial membrane potential in, MDA-MB-231 cancer cells when used at a concentration of 50 µM. Ferroptosis inducer 24 also increases the levels of reactive oxygen species (ROS) in a time-dependent manner.Formal Name: 3-phenyl-2-propenoic acid, 2-(1H-indol-3-yl)ethyl ester. CAS Number: 28657-88-7. Molecular Formula: C19H17NO2. Formula Weight: 291.3. Purity: >95%. Formulation: (Request formulation change), A solid. Solubility: DMSO: Soluble: >10 mg/ml, Ethanol: Sparingly Soluble: 1-10 mg/ml. SMILES: O=C(/C=C/C1=CC=CC=C1)OCCC2=CNC3=CC=CC=C32. InChi Code: InChI=1S/C19H17NO2/c21-19(11-10-15-6-2-1-3-7-15)22-13-12-16-14-20-18-9-5-4-8-17(16)18/h1-11,14,20H,12-13H2/b11-10+. InChi Key: UKBRRPUKMUGTQR-ZHACJKMWSA-N.