DY 268

DY 268 is a farnesoid X receptor (FXR) antagonist (IC50 = 7.5 nM in a time-resolved FRET assay). It inhibits FXR transactivation in a cell-based assay with an IC50 value of 468 nM.Formal Name: 1-[(3-methoxyphenyl)methyl]-N-[4-methyl-3-(4-morpholinylsulfonyl)phenyl]-3-(4-methylphenyl)-1H-pyrazole-4-carboxamide. CAS Number: 1609564-75-1. Molecular Formula: C30H32N4O5S. Formula Weight: 560.7. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMSO: soluble. lambdamax: 250 nm. SMILES: CC(C=C1)=CC=C1C2=NN(CC3=CC=CC(OC)=C3)C=C2C(NC4=CC=C(C)C(S(N5CCOCC5)(=O)=O)=C4)=O. InChi Code: InChI=1S/C30H32N4O5S/c1-21-7-10-24(11-8-21)29-27(20-33(32-29)19-23-5-4-6-26(17-23)38-3)30(35)31-25-12-9-22(2)28(18-25)40(36,37)34-13-15-39-16-14-34/h4-12,17-18,20H,13-16,19H2,1-3H3,(H,31,35). InChi Key: KQSPAAPFKIEUGH-UHFFFAOYSA-N.