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Item number | Size | Datasheet | Manual | SDS | Delivery time | Quantity | Price |
---|---|---|---|---|---|---|---|
Cay38531-1 | 1 mg | - |
6 - 10 business days* |
168.00€
|
|||
Cay38531-5 | 5 mg | - |
6 - 10 business days* |
753.00€
|
If you have any questions, please use our Contact Form.
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
You can also order by e-mail: info@biomol.com
Larger quantity required? Request bulk
DNPH1i is an inhibitor of 2'-deoxynucleotide 5'-phosphate N-hydrolase 1 (DNPH1). It inhibits... more
Product information "DNPH1i"
DNPH1i is an inhibitor of 2'-deoxynucleotide 5'-phosphate N-hydrolase 1 (DNPH1). It inhibits DNPH1 activity toward the DNPH1 substrate 5-hydroxymethyl-2'-deoxyuridine (hmdU) when used at a concentration of 100 µM. DNPH1i (0.3 µM) reduces the viability of BRCA1-deficient SUM149 cells containing single-guide RNA against p53-binding protein 1 (sg53BP1) when used in combination with hmdU but not when used alone. It also reduces the viability of hematological cancer cells, including CEM, HL-60, K562, and RPMI-8226 cells (IC50s = 1.3, 0.93, 5.9, and 4.6 µM, respectively), solid tumor cells, including MCF-7, HeLa, and HOS cells (IC50s = 3.7, 1.9, and 13.6 µM, respectively), and G-361 malignant melanoma cells (IC50 = 15 µM) but also reduces viability of BJ fibroblasts (IC50 = 1.7 µM).Formal Name: N-(phenylmethyl)-adenosine. CAS Number: 4294-16-0. Synonyms: 2'-Deoxynucleotide 5'-Phosphate N-hydrolase 1 Inhibitor, Benzyladenine Riboside, N6-Benzyladenosine, NSC 70423. Molecular Formula: C17H19N5O4. Formula Weight: 357.4. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Methanol: Soluble. SMILES: O[C@H]1[C@H](N2C3=NC=NC(NCC4=CC=CC=C4)=C3N=C2)O[C@H](CO)[C@H]1O. InChi Code: InChI=1S/C17H19N5O4/c23-7-11-13(24)14(25)17(26-11)22-9-21-12-15(19-8-20-16(12)22)18-6-10-4-2-1-3-5-10/h1-5,8-9,11,13-14,17,23-25H,6-7H2,(H,18,19,20)/t11-,13-,14-,17-/m1/s1. InChi Key: MRPKNNSABYPGBF-LSCFUAHRSA-N.
Keywords: | 2'-Deoxynucleotide 5'-Phosphate N-hydrolase 1 Inhibitor, Benzyladenine Riboside, N6-Benzyladenosine, NSC 70423, N-(phenylmethyl)-adenosine |
Supplier: | Cayman Chemical |
Supplier-Nr: | 38531 |
Properties
Application: | DNPH1 inhibitor |
MW: | 357.4 D |
Formula: | C17H19N5O4 |
Purity: | >98% |
Format: | Solid |
Database Information
CAS : | 4294-16-0| Matching products |
KEGG ID : | K22928 | Matching products |
Handling & Safety
Storage: | -20°C |
Shipping: | -20°C (International: -20°C) |
Signal Word: | Warning |
GHS Hazard Pictograms: |
|
H Phrases: | H302, H315, H319, H335 |
P Phrases: | P261, P264, P270, P271, P280, P301+310, P302+352, P304+340, P305+351+338, P312, P321, P330, P332+313, P337+313, P362+364, P403+233, P405, P501 |
Caution
Our products are for laboratory research use only: Not for administration to humans!
Our products are for laboratory research use only: Not for administration to humans!
Information about the product reference will follow.
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