DMU2139

DMU2139 is an inhibitor of the cytochrome P450 (CYP) isoform CYP1B1 (IC50 = 0.009 µM). It is selective for CYP1B1 over CYP1A1, CYP1A2, CYP3A4, and CYP2D6 (IC50s = 0.795, 1.2, 10.6, and 5 µM, respectively). DMU2139 enhances cisplatin-induced cell death in HEK293 cells overexpressing CYP1B1.Formal Name: 1-(6-methoxy-2-naphthalenyl)-3-(3-pyridinyl)-2-propen-1-one. CAS Number: 104890-70-2. Molecular Formula: C19H15NO2. Formula Weight: 289.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: DMF: 10 mg/ml. lambdamax: 232 nm. SMILES: O=C(C1=CC=C2C=C(C=CC2=C1)OC)C=CC3=CN=CC=C3. InChi Code: InChI=1S/C19H15NO2/c1-22-18-8-7-15-11-17(6-5-16(15)12-18)19(21)9-4-14-3-2-10-20-13-14/h2-13H,1H3. InChi Key: MPDPEUALCUWORP-UHFFFAOYSA-N.