Dihydromethysticin

Dihydromethysticin is a kavalactone originally isolated from P. methysticum (kava-kava) that has diverse biological activities, including efflux transporter inhibitory, antinociceptive, and neuroprotective properties. Dihydromethysticin is a P-glycoprotein (P-gp) inhibitor that increases uptake of the P-gp substrate calcein AM (Cay-14948) by 50% in P388 mouse leukemia cancer cells overexpressing P-gp when used at a concentration of 54.6 µM. Dihydromethysticin (275 mg/kg) has analgesic activity, increasing the latency to tail withdrawal in the tail-flick assay in mice. It also decreases the infarct size in a mouse model of ischemia induced by microbipolar coagulation of the left middle cerebral artery (MCA) when administered at a dose of 10 mg/kg.Formal Name: (6S)-6-[2-(1,3-benzodioxol-5-yl)ethyl]-5,6-dihydro-4-methoxy-2H-pyran-2-one. CAS Number: 19902-91-1. Synonyms: DHM, 7,8-dihydro Methysticin, NSC 112159. Molecular Formula: C15H16O5. Formula Weight: 276.3. Purity: >98%. Formulation: (Request formulation change), A solid. Solubility: Chloroform: soluble, Methanol: soluble. SMILES: O=C1O[C@@H](CCC2=CC=C(OCO3)C3=C2)CC(OC)=C1. InChi Code: InChI=1S/C15H16O5/c1-17-12-7-11(20-15(16)8-12)4-2-10-3-5-13-14(6-10)19-9-18-13/h3,5-6,8,11H,2,4,7,9H2,1H3/t11-/m0/s1. InChi Key: RSIWXFIBHXYNFM-NSHDSACASA-N. Origin: Synthetic.